Intestinal proinflammatory macrophages induce a phenotypic switch in interstitial cells of Cajal
نویسندگان
چکیده
منابع مشابه
Sodium current in human intestinal interstitial cells of Cajal.
Interstitial cells of Cajal (ICC) generate the electrical slow wave required for normal gastrointestinal motility. The ionic conductances expressed in human intestinal ICC are unknown. The aim of this study was to determine expression of a Na+ current in human intestinal ICC and to determine the effects of the Na+ current on the slow wave. Visually identified, freshly dissociated, single ICC we...
متن کاملInterstitial cells of Cajal and intestinal function in Trinidadian children.
OBJECTIVE This study was carried out to compare the density of the interstitial cells of Cajal (ICCs) in the bowel wall of children with Hirschsprung's disease (HD), anorectal malformations (ARM) and normal controls in Trinidad and Tobago. SUBJECTS AND METHOD Segments of bowel wall excised from eight children with HD, three controls and two children with ARM were immunostained with c-Kit prim...
متن کاملInterstitial Cells of Cajal – Pacemakers of the Intestinal Musculature
The paper reviews the present-day knowledge on the origin, location, morphology, function, and identification of interstitial cells of Cajal (ICC). ICC include several types of mesenchymal cells, spindle-shaped or stellate, found within the musculature of the gastrointestinal tract. Some types of ICC act as pacemakers of the intestinal musculature, while others are implicated in the modulation ...
متن کاملthe relationship between intestinal motility and interstitial cells of cajal in nonalcoholic fatty liver mice
background nonalcoholic fatty liver disease (nafld) is the most common cause of chronic liver disease in western world. however, nafld shows an increasing trend in china every year, which has attracted the attention of national health authorities. the previous studies have shown that nafld caused severe gastrointestinal motor disorders, but little is known about the interstitial cells of cajal ...
متن کاملActivation of intestinal smooth muscle cells by interstitial cells of Cajal in simulation studies.
Activation of a two-dimensional sheet network (5 parallel chains of 5 cells each) of simulated intestinal smooth muscle cells (SMCs) by one interstitial cell of Cajal (ICC) was modeled by PSpice simulation. The network of 25 cells was not interconnected by gap-junction channels; instead, excitation was transmitted by the electric field that develops in the junctional clefts (JC) when the prejun...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2020
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci126584